The correlation between S186N gene polymorphism and the premature infants with respiratory distress syndrome in Mongolian and Han ethnic
10.3760/cma.j.issn.1671-0282.2018.06.008
- VernacularTitle:蒙汉族早产儿呼吸窘迫综合征与S186N基因多态性相关性研究
- Author:
Hua MEI
1
;
Chun XIN
;
Yuheng ZHANG
;
Chunzhi LIU
;
Yayu ZHANG
;
Chunli LIU
;
Dan SONG
;
Jinzhu MA
Author Information
1. 内蒙古医科大学附属医院新生儿科
- Keywords:
S186N;
Respiratory distress syndrome;
Mongolian nationlity;
Han nationlity;
premature infants;
Gene polymorphism;
Pulmonary surfactant surfactant proteinC;
Exon
- From:
Chinese Journal of Emergency Medicine
2018;27(6):611-614
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between pulmonary surfactant protein C exon5 area's gene polymorphism and the premature infants with respiratory distress syndrome (RDS) among Mongolian and Han ethnic in Inner Mongolia District. Methods Fifty unrelated Mongolian RDS premature infants (28 weeks ≤ gestational age <37 weeks) were recruited as study group (31 male and 19 female), and another 50 unrelated Han ethnic RDS premature infants (28 weeks ≤ gestational age<37 weeks) were enrolled at the same time, as control group (27 male and 23 female).Polymerase chain reaction was used for gene polymorphism analysis and gene detection technology was employed to determine the sequence of SP-C gene exon5 area, respectively. At last, the difference in genotype frequency of SP-C gene exon 5 area C. 715G>A(S186 N) was compared between two groups. Results There were three genotypes could be checked out from SP-C gene exon 5 area C. 715G>A(S 186N)locus; namely GG,AA,AG types, and in study group, genotype frequencies of these three genotypes were 28％, 62％ and 10％, respectively, and G allele frequency was 33％, and A allele frequency was 67％. Genotype frequencies in control group were 78％, 10％ and 12％, respectively, and G allele frequency was 84％, A allele frequency was 16％. The A allele genotype frequency in study group at SP-C exon 5 area C. 715G>A(S186N) significantly higher than that in control group. There was statistically significant difference in alleles variations between two groups (χ2 = 53.300, P＜ 0.05). Conclusions SP-C exon 5 area C. 715G>A(S 186N)locus polymorphism related to Inner Mongolia Mongolian premature RDS. Individuals carrying SP-C exon 5 area C. 715G>A (S186N) A alleles have higher risk of suffering from RDS.
