The value of serum N-terminal pro brain natriuretic peptide in predicting left ventricular diastolic dysfunction in septic shock patients
10.3760/cma.j.issn.1671-0282.2018.02.011
- VernacularTitle:N末端脑钠肽前体对脓毒症休克患者左心室舒张功能障碍的预测价值
- Author:
Linxia SHEN
1
;
Ya'an ZHENG
;
Zhaoxing TIAN
Author Information
1. 北京大学第三医院急诊科
- Keywords:
Sepsis;
Septic shock;
Left ventricular diastolic dysfunction;
N-terminal pro brain natriuretic peptide;
Troponin Ⅰ;
Creatinine;
Early diastolic transmitral velocity;
Early mitral anulus diastolic velocity
- From:
Chinese Journal of Emergency Medicine
2018;27(2):164-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum N-terminal pro brain natriuretic peptide NT-proBNP in left ventricular diastolic dysfunction(LVDD) in septic shock patients.Methods According to retrospective analysis of clinical data 96 patients with septic shock were divided into LVDD group and non-LVDD group.General clinical data,APACHE scores,NT-proBNP,Troponin I(TNI),creatinine,procalcitonin,D-dimer and lactic acid within the first 24 hours after admission were recorded,and multi-factors logistic regression analysis was conducted to find independent risk factors for left ventricular diastolic dysfunction in septic shock patients Receiver operating characteristic curve ROC was constructed to indicate the predictive value.Results There were no significant differences in general clinical data,procalcitonin,D-dimer and lactic acid between two groups.Compared with non-LVDD group the levels of NT-proBNP [lgNT-proBNP (3.66±0.38) vs.(3.03±0.59),P =0.000],TNI [lgTNI(-1.45±0.86)vs.(-2.36±0.82),P ＜ 0.01] and creatinine [(186.12±124.24)vs.(101.16±57.01),P ＜ 0.01] in LVDD group were significantly higher.It was shown by multi-factors logistic regression analysis that NT-proBNP (OR=8.731,95％CI;1.541-49.466,P=0.014) was an independent risk factor for left ventricular diastolic dysfunction in septic shock patients.The area under the curve AUC of NT-proBNP was 0.813 with the cut-off value of 1 725 pg/μL,sensibility =88.6％,specificity =62.1％.Conclusion NT-proBNP was avaluable indicator in predicting left ventricular diastolic dysfunction in septic shock patients.
