Fabrication and characterization of three-dimensional cartilage nano-scaffolds based on extracellular matrix
10.7644/j.issn.1674-9960.2017.12.012
- VernacularTitle:基于细胞外基质特性构建三维软骨纳米支架材料及表征
- Author:
Huai-Yang LIU
1
;
Jing GUAN
;
Juan WEI
;
Zhi-Hong LI
;
Song LIN
;
Shu-Jie HUANG
;
Ji-Min WU
Author Information
1. 军事科学院系统工程研究院卫勤保障技术研究所
- Keywords:
extracellular matrix;
stents;
nanostructures;
electrospinning;
collagen;
hyaluronic acid;
chondroitin sulfate;
tissue engineering
- From:
Military Medical Sciences
2017;41(12):998-1003
- CountryChina
- Language:Chinese
-
Abstract:
Objective To produce three-dimensional cartilage nanoscaffolds based on extracellular matrix.Methods Nanoscaffolds of collagen type Ⅱ(Col-Ⅱ), hyaluronic acid(HA)and chondroitin sulfate(CS)were prepared by mixing water,trifluoroethanol and hexafluoroisopropanol as a solvent.The structure, morphology, thermal property, mechanical performance and hydrophobicity of the scaffolds were characterized.Results There were interactions between Col-Ⅱ,HA and CS.The scaffolds were hydrophobic.The Col-Ⅱ triple-helix structure wasn't completely damaged.In the study, scaffold fibers were smooth,slender and dimensionally stable.The scaffolds had good thermal stability and optimal tensile properties could be obtained at the mass ratio of 7:1:1.Conclusion In this study, scaffolds have good thermal, mechanical and structural properties and are expected to be used in cartilage repair.
