Diagnostic efficiency and result of prostate biopsy for patients with t-PSA between 4.0 and 10 ng/ml

VernacularTitle:总前列腺特异性抗原在4～10ng/ml水平时前列腺穿刺活检的诊断效能及结果
Author: Jian-Nan LIU ¹ ; Hai-Xing MAI ; Nan QU ; Xue-Chao LI ; Ya-Lin WANG ; Chen HUANG ; Li-Jun CHEN
Author Information

1. 军事医学科学院附属医院泌尿外科
Keywords: prostate-specific antigen; prostate biopsy; Meta-analysis; Gleason grade
From:Military Medical Sciences 2017;41(10):825-829
CountryChina
Language:Chinese
Abstract: Objective To investigate the diagnostic efficiency and result of prostate biopsy for patients with t -PSA between 4.0 and 10 ng/ml.Methods This analysis was based on 20 qualified research papers from such lectronic databases as PubMed, MEDLINE, EMBASE and Cochrane from January 2010 until September 2017.Data extracted was analyzed using classic Meta-analysis with R software .The random or fixed effect model analysis was used to estimate the rate.Heterogeneity was analyzed using I 2 statistic.Results Totally 5481 patients were included in the 20 research papers. The positive rate of prostate biopsy was 20.6％, with t-PSA between 4.0 and 10 ng/ml, which was higher than the rate in the data from CUA Guide(2014).The difference was statistically significant .Conclusion Patients should be subjected to prostate biopsy if their t-PSA ranges 4.0 from 10 ng/ml regardless of the rate of f/t-PSA.The Gleason grade is relatively low when PSA is in the gray area , and the risk is also low.