Serological characteristics and gene mutation analysis of Para-Bombay blood group
10.7644/j.issn.1674-9960.2017.10.008
- VernacularTitle:类孟买血型血清学特点及基因突变分析
- Author:
Xiao-Qin ZHOU
1
;
Zhi-Hui SHEN
;
Nai-Cong ZHANG
;
Song JIN
;
Sheng-Qiang LIANG
Author Information
1. 解放军175医院
- Keywords:
Para-Bombay blood group;
serological identification;
FUT1;
FUT2;
gene sequencing
- From:
Military Medical Sciences
2017;41(10):822-824
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the Para-Bombay blood group on the basis of its serological characteristics .Methods ABO blood typing , H antigen detection , absorption and elution test , and saliva neutralization test were conducted for serological identification of ABO blood group .PCR-SSP was used to sequence FUT1 and FUT2 genes.Results Results of ABO genotyping of eight individuals of the Para-Bombay blood group were consistent with results of their serological blood typing.Among these cases, there were 3 cases of Amh,4 cases of Bmh,and 1 case of Abmh.The results of their FUT1 genotyping were h1h1 in 3 cases, h2h2 in 2 cases and h1h2 in 3 cases.Conclusion The differentce of agglutination intensity between Ac and Bc in reverse ABO blood typing and abnormal Oc agglutination is of greet significance for Para -Bombay blood group.
