Preformulation study on novel antiviral drug GZ914
10.7644/j.issn.1674-9960.2017.10.006
- VernacularTitle:新型抗病毒药物GZ914处方前研究
- Author:
Guan-Hua HOU
1
;
Xiao-Yang HAN
;
Yan-Jun CHEN
;
Qian JIN
;
Yu-Li WANG
;
Qiang WU
Author Information
1. 河南大学药学院
- Keywords:
GZ914;
preformulation;
oil/water partition coefficient;
solubility
- From:Military Medical Sciences
2017;41(10):810-813,863
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the physical-chemical parameters of antiviral drug GZ 914 and provide data for the preparation design .Methods The appearance , crystal structure and solubility of GZ 914 were investigated .An HPLC method was established to determine the content of GZ 914 in vitro before oil/water partition coefficient and solubility in different pH experiments were calculated .Results GZ914 was a straw yellow powder with a crystalline structure , low water-solubility and good lipotropy .The HPLC method had a good linear relationship within the range of 12-60 μg/ml (r=0.9998).The oil/water partition coefficient of GZ914 was 1.9.Conclusion This analytical method is accurate and reliable.The oil/water partition coefficient indicates that the drug could be formulated as an oral solid preparation.
