Series review of radioembolization with yttrium-90 microspheres (Part Ⅳ): dose calculation of yttrium-90 microspheres
10.3969/j.issn.1008-794X.2018.01.022
- VernacularTitle:钇-90微球的剂量计算——钇-90微球放射栓塞系列回顾(四)
- Author:
Zhongzhi JIA
1
;
Shuangshuang XIE
;
Lili ZHENG
;
Sini WANG
;
Weiping WANG
Author Information
1. 213003江苏常州,南京医科大学附属常州市第二人民医院介入血管科
- Keywords:
yttrium-90;
dose;
lung shunt fraction;
tumor burden
- From:
Journal of Interventional Radiology
2018;27(1):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Accurate doses of yttrium-90 (90Y) microspheres are critical for the treatment of liver malignancies,because it is closely related to the clinical efficacy and adverse reactions.The dose calculationis primarily based on the type of ~Y delivery medium,whether it is glass microsphere (TheraSpheres) or resin microsphere (SIR-Spheres).The dose calculation of glass microspheres is based on the assumption that the expected radiation dose of the liver and the microspheres can be evenly distributed throughout the liver,while the dose calculation of resin microspheres is based on the assumption that the microspheres are not uniformly distributed throughout the liver,and the degree of this inhomogeneous distribution depends on the extent to which the normal liver is replaced by the tumor tissue.Many other factors may also potentially affect the therapeutic dose of 90Y microspheres.This review will introduce the calculation methods of 90Y microsphere dose,and describe the factors that need to be considered in order to achieve maximum efficacy and avoid adverse effects.
