The establishment of animal model with liver cancer and the experimental interventional procedure
10.3969/j.issn.1008-794X.2017.11.020
- VernacularTitle:肝癌动物模型与介入实验操作应用
- Author:
Yang GUAN
1
;
Fengyong LIU
;
Jinxin FU
;
Xianxian CHEN
;
Jinshuan XING
;
Shibin WEI
;
Maoqiang WANG
Author Information
1. 100853,北京 解放军总医院介入放射科
- Keywords:
animal model;
animal experiment;
hepatocellular carcinoma;
interventional radiology
- From:
Journal of Interventional Radiology
2017;26(11):1046-1051
- CountryChina
- Language:Chinese
-
Abstract:
For the treatment of liver tumors,interventional therapy is becoming more and more important.The development of interventional therapy relies on the development and application of new materials,new equipment and new drugs,and the preclinical animal testing of these applications is an important part of assessing the safety and effectiveness of interventional procedures.The animal HCC model plays an important leading role in exploring the new approach of interventional therapy.However,the animal HCC models which are suitable for experimental researches are limited,at present,the animal HCC models are mainly confined to rats and rabbits.Due to the limitation of animal body shape,routine interventional instruments and equipment are not suitable to perform interventional procedures for some small animals.Nowadays,there is still a shortage of devices for interventional hepatic artery surgery in mice,and interventional instruments for rats are also limited.This paper aims to make a summary about the types of HCC model in rats and rabbits which are often used in the experimental researches,the modeling methods,the interventional procedures,the anesthesia and imaging examinations,etc.
