Application of quantitative arterial enhancement fraction of multiphase perfusion CT imaging in evaluating the curative effect of transcatheter arterial chemoembolization for hepatocellular carcinoma
10.3969/j.issn.1008-794X.2017.11.006
- VernacularTitle:CT灌注参数动脉增强分数值在评估肝癌TACE术后疗效中的初步研究
- Author:
Lulu LIU
1
;
Zhewei ZHANG
;
Yongbo YANG
;
Linyin FAN
;
Guoliang SHAO
;
Peipei PANG
Author Information
1. 310022,杭州 浙江省肿瘤医院放射科
- Keywords:
hepatocellular carcinoma;
CT perfusion imaging;
arterial enhanced fraction;
transcatheter arterial chemoembolization
- From:
Journal of Interventional Radiology
2017;26(11):988-992
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the application of routine CT three-phase perfusion parameter,that is arterial enhancement fraction (AEF) value,in evaluating the curative effect of transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).Methods The clinical data of a total of 30 patients with pathologically proved HCC were enrolled in this study.Routine CT three-phase perfusion scan was performed 1-3 days before as well as 30-40 days after TACE in all patients.AEF value was calculated by using CT Kinetics software (GE Healthcare).The formula for calculating AEF value was as follows:AEF value=(arterial phase CT value-plain scan CT value)÷(portal phase CT value-plain scan CT value).The results were statistically analyzed.Results Effective treatment group had 17 patients,and ineffective treatment group had 13 patients.The postoperative AEF values in the effective treatment group and the ineffective treatment group were (0.351±0.090) and (0.438±0.050) respectively,the difference between the two groups was statistically significant (P＜0.05).Taking postoperative AEF value of 0.392 as the critical value to predict the postoperative effect of TACE,the sensitivity and specificity were 86.7％ and 73.2％ respectively,and the area under the curve was 0.876 (P＜0.001).Conclusion The routine CT three-phase perfusion parameter (AEF) can quantitatively reflect the hemodynamic changes of HCC after TACE,which is helpful for making early evaluation of TACE effect,meanwhile,no additional radiation dose will be added.
