Feasibility study of the use of left atrial appendage occluder LACBES with animal experiment
10.3969/j.issn.1008-794X.2017.01.010
- VernacularTitle:LACBES左心耳封堵器及动物实验可行性研究
- Author:
Xue-Chao TANG
1
,
2
;
Fei-Yu WANG
;
Zhi-Gang ZHANG
;
Tong KAN
;
Yuan BAI
;
Xiao-Hua YOU
;
Xin-Miao HUANG
;
Xu-Dong XU
;
Shan-Shi GONG
;
Jia-Dong JI
;
Yong-Wen QIN
Author Information
1. 200433 上海 第二军医大学附属长海医院心内科
2. 解放军第88医院心内科
- Keywords:
left atrial appendage occluder;
LACBES occluder;
left atrial appendage occlusion;
animal experiment
- From:
Journal of Interventional Radiology
2017;26(1):44-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To introduce a self-developed left atrial appendage occluder,LACBES,and to explore the clinical feasibility of using it for the occlusion of left atrial appendage (LAA).Methods Eight healthy canines were used in this experimental study.The LAA of each canine was occluded with LACBES occluder through trans-femoral vein approach.After the procedure of occlusion,the compression ratio of the occluder was calculated,the residual shunt was assessed by left atrial angiography.The left atrium pressure was monitored before and after the procedure,and the immediate effect of LAA occlusion on the left atrium pressure was statistically analyzed.Results Implantation of LACBES occluder was successfully accomplished in all the eight canines.The compression ratio of the occluders ranged from 10％ to 15％.Small amount of postoperative residual shunt was detected in one canine.After occlusion two canines died of procedure-related complications,including shifting of occluder and formation of hematoma at puncturing site.No device-associated death occurred.After occlusion,the left atrial systolic pressure increased instantly,which went up from preoperative (25.4±2.8) mmHg to postoperative (27.5±3.4) mmHg (P＜0.05),but it returned to the baseline of (25.4±2.8) mmHg within 15 minutes.Conclusion For the occlusion of LAA,the use of LACBES occluder carries higher instant success rate and lower residual shunt rate with less device-associated complications,although the left atrial systolic pressure has a transient rising immediately after the occlusion.Therefore,it is expected that LACBES will be able to be applied in clinical practice.
