Clinical research of severe aplastic anemia with pulmonary invasive fungal infection after transplantation
10.11855/j.issn.0577-7402.2017.12.14
- VernacularTitle:重型再生障碍性贫血移植后合并肺部侵袭性真菌感染6例临床分析
- Author:
Zhi GUO
1
;
Hua REN
;
Liang-Ding HU
;
Chen XU
;
Yu-Hang LI
;
Jiang-Wei HU
;
Li-Ping CHEN
;
Hu CHEN
Author Information
1. 518116广东深圳,国家癌症中心/中国医学科学院北京协和医学院肿瘤医院深圳医院血液淋巴瘤科
- Keywords:
severe aplastic anemia;
allogeneic hematopoietic stem cell transplantation;
pulmonary;
invasive fungal infection
- From:
Medical Journal of Chinese People's Liberation Army
2017;42(12):1097-1101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical characteristics of pulmonary invasive fungal infection (IFI) in patients with severe aplastic anemia (SAA) after allogeneic hematopoietic stem cells transplantation (allo-HSCT).Methods The clinical data of 30 SAA patients received allo-HSCT in 307 Hospital of PLA from Jan.2012 to Jan.2015 were analyzed retrospectively.All the SAA patients accepted combined bone marrow with peripheral blood stem cells transplantation,and then the clinical features and outcome of pulmonary IFI after transplantation were analyzed.Results Six (20％) of the 30 SAA patients were complicated by IFI after transplantation,including 4 males and 2 females with average age of 18.3(6-42) years.All the 6 patients showed characteristic imaging changes in pulmonary,of which 3 cases were definitely diagnosed by bronchoscopy or sputum fungal culture,and the other 3 cases by imaging and clinical manifestation.Four cases were cured and 2 cases died after first-line antifungal therapy,the total mortality was 33.3％.Conclusion High incidence of complicated IFI in SAA patients after allo-HSCT may lead to the high mortality,it's necessary to give an empiric antifungal therapy as earlier as possible.
