Latest progress of the tumor suppressor gene and oncogene
10.3969/j.issn.1001-6325.2018.07.027
- VernacularTitle:抑癌基因与癌基因的最新研究进展
- Author:
Hai-Li LI
1
;
Chi-Hao SHAO
;
Ruo-Yu ZHOU
;
Yong-Jin ZHANG
;
Cui LI
;
Ying LUO
Author Information
1. 昆明理工大学 医学院 衰老与肿瘤分子遗传学实验室
- Keywords:
tumor suppressor gene;
oncogene;
precision medicine
- From:
Basic & Clinical Medicine
2018;38(7):1029-1033
- CountryChina
- Language:Chinese
-
Abstract:
Under normal circumstances, tumor suppressor gene monitors cellular proliferation signals and prevents abnormal cell proliferation through inhibiting cell cycle progress, promoting cell senescence or apoptosis, thus a-chieves the function of cancer inhibition. On the contrary, the function of oncogene is to facilitate cell to escape from cell cycle control and promote the cell proliferation. Oncogenes may also inhibit cell apoptosis and results in uncontrollable cell growth. However, tumor suppressor gene may be converted to oncogene in different cellular con-text and gene mutation status, and vice versa.
