Research progress of Notch signaling pathway in tumor
10.3969/j.issn.1001-6325.2018.07.026
- VernacularTitle:肿瘤Notch信号通路的研究进展
- Author:
Xiao-Qing WANG
1
;
Guo-Qiang YUAN
;
Ya-Wen PAN
Author Information
1. 兰州大学第二医院 神经病学研究所
- Keywords:
Notch signaling pathway;
tumor;
abnormal
- From:
Basic & Clinical Medicine
2018;38(7):1025-1028
- CountryChina
- Language:Chinese
-
Abstract:
Notch gene encodes a class of highly conserved cell surface receptors that determine the fate of cells in embryonic development and mature tissue, which is an important pathway of communication between adjacent cells, and then regulates of cell development, proliferation and apoptosis. The occurrence and progression of multiple tumors are associated with abnormal Notch signaling pathways. For different tumors, it is important significance for anti-tumor therapy to effectively regulate the Notch participants and target molecules.