Research progress of macrophage autophagy in atherosclerosis
10.3969/j.issn.1001-6325.2018.07.025
- VernacularTitle:巨噬细胞自噬在动脉粥样硬化中作用的研究进展
- Author:
Si-Yu MI
1
;
Ying ZHOU
;
Jing-Qiao WANG
;
Mao-Qing TONG
;
Xiao-Min CHEN
Author Information
1. 宁波大学 医学院
- Keywords:
atherosclerosis;
macrophages;
autophagy
- From:
Basic & Clinical Medicine
2018;38(7):1020-1024
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a self-protecting cell catabolic pathway. That macrophages involved in lipid metabolism dis-orders are the basis of atherosclerotic lesions. Autophagy plays an important role in the inhibition of inflammation and apoptosis and the promotion of cholesterol efflux. The macrophage autophagy can promote lipid metabolism, re-duce the formation of foam cells and inflammation signal, thereby inhibit atherosclerosis. Induction of macrophage autophagy may have potential significance in the treatment of atherosclerosis.
