Effects of metformin on insulin sensitivity and islet beta cell secretion in obesity patients
10.3969/j.issn.1001-6325.2018.07.006
- VernacularTitle:二甲双胍对肥胖症患者胰岛素敏感性和胰岛β细胞分泌的影响
- Author:
Yu ZHANG
1
;
Hui-Juan ZHU
;
Lin-Jie WANG
;
Hong-Bo YANG
;
Shi CHEN
;
Yu-Xing ZHAO
;
Hui PAN
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院 内分泌科 卫计委内分泌重点实验室 协和转化医学中心
- Keywords:
metformin;
insulin sensitivity;
insulin secretion;
islet beta cell
- From:
Basic & Clinical Medicine
2018;38(7):928-932
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of metformin on insulin sensitivity and secretion in patients with obesity and insulin resistance. Methods This study enrolled 42 obesity patients with insulin resistance who were regularly followed-up in Peking Union Medical College Hospital from September 2012 to May 2016. They were divided into two groups according to their different status of glucose metabolism: normal glucose tolerance( NGT) and impaired glucose regulation( IGR) . Life style intervention and metformin were given to all these patients. The antropometric and metabolic data were collected before treatment, 3 and 6 months after treatment respectively. Results 42 patients, aged (23.6±6.5) years, including 11 males and 31 females were enrolled. 19 of them were NGT and 23 were IGR (8 of IGT and 15 of IFG) . Among all these patients, fasting insulin was significantly higher at 3 months after treatment(P＜0.05).The same results were shown in group-NGT(P＜0.05). Fasting insulin was significantly lower at 6 months after treatment than at baseline among all patients( P＜0.05) . HOMA-IR showed no significant difference between the baseline and 3 months after treatment, but significantly higher at baseline and 3 months after treatment than 6 months after therapy( P＜0.001) . HOMA-beta was significantly( P＜0.001) lower be-fore treatment and 6 months treatment the effect was more significant than 3 months after treatment among all pa-tients. HOMA-beta was significantly lower at baseline in group-IGR than at baseline in group-NGT ( P＜0.05) . Conclusions The effect of metformin on insulin secretion is earlier than that of improving the insulin sensitivity in patients with obesity and insulin resistance. Metformin is more likely to promote insulin secretion in patients with normal glucose tolerance than those with IGR within 3 months of intervention.
