Research progress on translesion synthesis DNA polymerase ζ-Rev7 in tumor development
- VernacularTitle:跨损伤合成DNA聚合酶ζ-Rev7在肿瘤发展中的研究进展
- Author:
Ju-Hua CAO
1
;
Liang-Zhi WANG
Author Information
1. 中国人民解放军第102医院内科
- Keywords:
DNA polymerase zeta ζ;
Rev7;
tumor
- From:
Basic & Clinical Medicine
2018;38(5):727-730
- CountryChina
- Language:Chinese
-
Abstract:
Translesion DNA synthesis is a kind of post-replication repair process, which mainly involves DNA polymerase kappa, eta and zeta.Translesion synthesis is a tolerance mechanism of DNA damage inside the cell, in which DNA polymerase zeta plays an important role.DNA polymerase zeta is mainly composed of subunits Rev7 and Rev3, and play a main role of participate in the damage repair in cell metabolism.Rev7(also known as MAD2L2)is a multifunctional protein that can be combined with a variety of proteins to participate in DNA dam-age repair, cell cycle regulation, gene expression and carcinogenesis, which is also involved in the prognosis of various adverse tumors.
