An overview of mechanism research on Helicobacter pylori pathogenic factors
- VernacularTitle:幽门螺杆菌致病因子作用机制研究概述
- Author:
Yue BI
1
;
Wei LUO
;
Hai-Ying GU
Author Information
1. 宁波大学医学院
- Keywords:
Helicobacter pylori;
virulence factor;
pathogenesis
- From:
Basic & Clinical Medicine
2018;38(5):713-716
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori(Hp)is considered to be closely associated with gastritis,peptic ulcer,gastric cancer and other gastrointestinal diseases,but the detail of the pathogenesis is still unclear.The past researches often fo-cused on virulence factors such as CagA(cytotoxin-associated gene/protein A),VacA(vacuolating cytotoxin A), Urease and DupA(duodenal ulcer-promoting gene/protein A),but these are not enough to demonstrate the patho-genic mechanism.Recent studies have not only revealed some new progresses of these past virulence factors but also found that Hp flagllum,adhesion protein and hemolysin play important roles in the pathogenic mechanism.
