Effect of ACE/Ang Ⅱ/AT1 axis and ACE2/Ang(1-7)/Mas axis on glucose and lipid metabolism in adipose tissue
- VernacularTitle:ACE/AngⅡ/AT1轴和ACE2/Ang(1-7)/Mas轴对脂肪组织糖脂代谢的影响
- Author:
Chi-Fa MA
1
;
Ting-Ting SHI
;
Ming-Xia YUAN
Author Information
1. 首都医科大学附属北京同仁医院内分泌科糖尿病防治研究北京市重点实验室
- Keywords:
renin-angiotensin system;
ACE/AngⅡ/AT1 axis;
ACE2/Ang(1-7)/Mas axis;
adipose tissue;
glucose and lipid metabolism
- From:
Basic & Clinical Medicine
2018;38(5):708-712
- CountryChina
- Language:Chinese
-
Abstract:
The renin angiotensin system(RAS)includes two counterbalance axes:the ACE/Ang Ⅱ/AT1 axis and the ACE2/Ang(1-7)/Mas axis.The RAS can regulate glucose and lipid metabolism in adipose tissue.Most of evi-dences demonstrated that the ACE/Ang Ⅱ/AT1 axis can induce glucose metabolism disorders in adipose tissue, while ACE2/Ang(1-7)/Mas axis improves glucose metabolism.The RAS,which is over activated in obese patient, has been considered to be a potential link among obesity,dyslipidemia and insulin resistance.The effect of ACE/AngⅡ/AT1 axis and ACE2/Ang(1-7)/Mas axis on lipid and glucose metabolism in adipose tissue should be futh-er investigated,and we may find a new target for improving glucose and lipid metabolism.