Effects of Wnt3a and Wnt5a signaling pathway switching on hematopoietic stem cells senescence
- VernacularTitle:Wnt3a与Wnt5a信号途径转换对造血干细胞衰老的影响
- Author:
Shuang LI
1
;
Qian-Qian SUN
;
Li-Mei YU
;
Chun-Hua ZHAO
Author Information
1. 遵义医学院附属医院贵州省细胞工程重点实验室
- Keywords:
hematopoietic stem cells;
senescence;
Wnt3a;
Wnt5a
- From:
Basic & Clinical Medicine
2018;38(5):703-707
- CountryChina
- Language:Chinese
-
Abstract:
Hematopoietic stem cells(HSCs)senescence is an important reason of hematopoietical and immunologi-cal function senescence.It also is play a key role during aging-related diseases development.Under certain condi-tions,the activation of classical Wnt 3a/β-catenin is in favour of maintains polarity and young states of HSCs,self-renewing,proliferation and differentiation potency.Switching to the non-classical Wnt5a pathway,further activation of Cdc42 protein and others can promote HSCs ageing,and indirectly inhibits Wnt3a/beta-catenin pathway.The in-tervention of two Wnt signaling pathways switching and mechanism,not only can illustrate the mechanism of HSCs aging,but also clear how to slow down ageing.This could provide a new strategy on the solution of age-related dis-eases and keeping a young state.
