Pathological changes of arota in long-term pure hyperuricemia rat
- VernacularTitle:长期单纯高尿酸血症大鼠主动脉病理变化
- Author:
Shu-Fen LIU
1
;
Qi WANG
;
Ya MA
;
Xue-Jun ZENG
Author Information
1. 中国医学科学院北京协和医学院北京协和医院物理医学康复科
- Keywords:
hyperuricemia;
animal model
- From:
Basic & Clinical Medicine
2018;38(5):692-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify whether long-term hyperuricemia(HU)is able to induce arota pathological changes in rat.Methods 2%OA forage and 100 μmol/L uric acid plus OA lavage were used to copy a long-term hyperuricemia animal model,eNOS,ET-1,ICAM expression in arota was evaluated to find out the role of uric acid in cardiovascular diseases.Results The arotas of hyperuricemia rats had tiny damages whereas that of rats in con-trol group was totally normal; Hyperuricemia rat had less eNOS expression,more ET-1,ICAM expression in arota (P<0.05)and less NO,more ET-1,ICAM in serum.Conclusions Long-term hyperuricemia is able to induce im-pairment in endothelium in rat arota,but fails to cause atherosclerosis.
