Expression of miR-181b-5p in peripheral blood from patients with esophageal cancer is down-regulated
- VernacularTitle:食管癌患者外周血中miR-181b-5p表达水平下降
- Author:
Gulnigar XOHRAT·
1
;
Yan-Jiao WANG
;
ABUDUREHEMAN·Zulipikaer
;
YUSUPJAN·Nazira
;
BAKRI·Iskandar
Author Information
1. 新疆医科大学基础医学院生物化学与分子生物学教研室
- Keywords:
esophageal cancer;
peripheral blood;
miRNA chip;
miR-181b-5p
- From:
Basic & Clinical Medicine
2018;38(5):600-603
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of miR-181b-5p in peripheral blood of patients with esophageal cancer and to develop a guidance for the diagnosis and prognosis of esophageal cancer.Methods Blood samples were collected from 34 cases of esophageal cancer and 26 cases of healthy volunteers.The single candidate miRNA from WBC was selected by RNA miRNAs chip screening analysis.Then the expression of the candidate miRNA was detected by RT-qPCR.Results Compares with the normal group,the expression of miR-181b-5p was down-regula-ted in esophageal cancer group.Conclusions The expression of miR-181b-5p in esophageal cancer is down regula-ted,which may be related to the occurrence and development of esophageal cancer.
