Role of programmed cell death receptor 1 signaling pathway in cancer immunotherapy
10.3969/j.issn.1001-6325.2018.04.032
- VernacularTitle:细胞程序性死亡受体1信号通路在肿瘤免疫疗法中的应用
- Author:
Wei-Peng XIONG
1
Author Information
1. 科罗拉多大学医学院 医学系
- Keywords:
tumor;
immunotherapy;
programmed cell death receptor 1;
antibody drug
- From:
Basic & Clinical Medicine
2018;38(4):578-582
- CountryChina
- Language:Chinese
-
Abstract:
Research in immunotherapy has achieved important progress in tumor treatment. Programmed cell death receptor 1(PD-1) is mainly expressed on the T lymphocyte surface and serves as an important immune regu-lator. The interactions of PD-1 and its ligand, PD-L1 are involved in tumor-induced immunosuppression. Some of the approved antibody preparations targeting PD-1/PD-L1 signaling showed significant clinical benefits.
