Cell biological properties of microglia and its role in neurons regulation
10.3969/j.issn.1001-6325.2018.04.029
- VernacularTitle:小胶质细胞生物学特性及对神经元调控作用
- Author:
Jie LI
1
;
Jun-Mei ZHOU
;
Shao-Wen TIAN
Author Information
1. 南华大学药学与生命科学学院
- Keywords:
microglia;
cell biological properties;
neuron
- From:
Basic & Clinical Medicine
2018;38(4):563-567
- CountryChina
- Language:Chinese
-
Abstract:
Microglia are resident immune cells within the brain parenchyma. In physiological conditions,microglia are highly dynamic, expressing multiple immune receptors and neurotransmitter receptors, tightly monitoring the microenvironment of central nervous system (CNS). Recent researches have revealed that these immune cells ac-tively modulate the functions of neurons,which potentially affecting neuronal activity and synaptic pruning,contrib-ute to synaptic plasticity and preventing neurotoxicity. The functional changes of microglia play an important role in the development,maturation and degeneration of the brain.
