Mitochondrial fusion-fission and heart failure
10.3969/j.issn.1001-6325.2018.04.027
- VernacularTitle:线粒体融合-分裂与心力衰竭
- Author:
Huan HU
1
;
Ping LI
;
Xiao-Shu CHENG
Author Information
1. 南昌大学第二附属医院 心血管内科
- Keywords:
mitochondria;
fusion;
fission;
heart failure
- From:
Basic & Clinical Medicine
2018;38(4):553-556
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial fusion,fission and dynamic transformation between the two are commonly known as mito-chondrial dynamics. Mitochondrial fusion-fission is related to a variety of biological functions of mitochondria inclu-ding regulation of energy metabolism, production of reactive oxygen species, maintenance of Ca2+homeostasis and influence of cellular death. Cardiac development,energy metabolism and ion homeostasis are closely related to the balance of mitochondrial fusion-fission.Mitochondrial fusion-fission disorders may cause myocardial cell dysfunction, damage and even the death of myocardial cells,which result in heart failure ultimately. Developing medicines tar-getting to reconstruct the balance of mitochondrial fusion-fission may provide new ideas and strategies for the treat-ment of chronic heart failure.
