Correlation between the expression of JARID1B/KDM5B in breast cancer tissues and the circulating tumor cells
10.3969/j.issn.1001-6325.2018.04.017
- VernacularTitle:乳腺癌组织中JARID1B/KDM5B的表达与血液循环肿瘤细胞相关性
- Author:
Li-Hua ZHAO
1
;
Jia WEI
;
Ying-Li HUAI
;
Xiao-Jing ZHANG
;
Chao ZHANG
;
Qiu-Lan LIN
;
Ke-Jie WANG
;
Hong-Yan YAN
;
Jia-Liang GUO
;
Qiu-Ying LI
Author Information
1. 民航总医院 病理科
- Keywords:
JARID1B/KDM5B;
invasive breast cancer;
imFISH
- From:
Basic & Clinical Medicine
2018;38(4):512-515
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between expression of JARID1B/KDM5B in invasive breast cancer tissue and circulating tumor cells of invasive breast patients. Methods The S-P immunohistochemical method was used to observe the expression of JARID1B/KDM5B in lesions.imFISH method was used to detect circulation tumor cells. Results Twenty-seven cases of patients showed CTC positive(the number of CTC was more than or equal to 2) in 35 invasive breast cancer cases,The results of JARID1B/KDM5B expression were as follows:(-) (n=0) and (+) in 1 case,(++) in 3 cases,(+++) in 23 cases,8 cases of negative cases (the number of CTC < 2), JARID1B/KDM5B immune group of results:(-) (n=2),(+) in 2 cases,(++) in 1 case,(+++) in 3 cases, The positive relation was found in expression of JARID1B/KDM5B and circulating tumor cells(P<0.05). Conclu-sions JARID1B/KDM5B positive expression in tumor tissues has a certain significance in predicting the recurrence and metastasis of tumor.
