Gut microbiota might be a new target for the intervention of essential hypertension
- VernacularTitle:肠道菌群是高血压干预的新靶点
- Author:
Hua JIN
1
Author Information
1. 甘肃中医药大学
- Keywords:
essential hypertension;
gut microblota
- From:
Basic & Clinical Medicine
2018;38(3):413-417
- CountryChina
- Language:Chinese
-
Abstract:
The essential hypertension is not only the syndrome but also the main cause of cardio-cerebrovascular disease. Based on analysis of the relations between gut microbiota and the clinical risk factors (glyeolipid metabo-lism disorder,obesity,atherosclerosis) of the essential hypertension, and the research on relationship between gut microbiota and circadian clock disturbance,gut microbiota and central blood pressure regulation,this article illus-trates the changes of the community characteristics of gut microbiota might affect on the occurrence and development of hypertension,also abnormality of the energy absorption,low level of gut derived endotoxin (lipopolysaccharide, LPS) and dysfunction of the gut barrier might play the most important role in this process,moreover,the microbio-ta-gut-brain axis is one of the important approaches.Combining with the increasing evidences which gut microbiota involved in the hypertension control,this article puts forward a viewpoint that gut microbiota might be a new target for the intervention of essential hypertension.
