Nutritional factors affecting adult neurogenesis and cognitive function
- VernacularTitle:营养因子影响成年神经再生和认知功能
- Author:
Yi-Qiong LIU
1
;
Yan ZHANG
Author Information
1. 北京大学 生命科学学院 膜生物学国家重点实验室
- Keywords:
hippocampal neurogenesis;
cognition;
neurodegeneration
- From:
Basic & Clinical Medicine
2018;38(3):304-307
- CountryChina
- Language:Chinese
-
Abstract:
Adult neurogenesis,a complex process by which stem cells in the hippocampal brain region proliferate and differentiate into new neurons and other resident brain cells,is known to be affected by many intrinsic and ex-trinsic factors,including diet. Neurogenesis plays a critical role in neural plasticity,brain homeostasis and mainte-nance in the central nervous system and is a crucial factor in preserving the cognitive function and repair of dam-aged brain cells affected by aging and brain disorders. Intrinsic factors such as aging,neuroinflammation,oxidative stress and brain injury, as well as lifestyle factors such as high-fat and high-sugar diets and alcohol consumption and opioid addiction,negatively affect adult neurogenesis.Conversely,many dietary components such as curcumin, resveratrol,blueberry polyphenols,polyunsaturated fatty acids (PUFAs), as well as caloric restriction, physical exercise and learning,have been shown to induce neurogenesis in adult brains. Although many of the underlying mechanisms by which nutrients and dietary factors affect adult neurogenesis have yet to be determined, nutritional approaches provide promising prospects to stimulate adult neurogenesis and combat neurodegenerative diseases and cognitive decline. In this review,we summarize the evidence supporting the role of nutritional factors in modifying adult neurogenesis and their potential to preserve cognitive function during aging.
