Connecting Alzheimer's disease to diabetes:Underlying mechanisms and potential therapeutic targets
- VernacularTitle:阿尔茨海默病和糖尿病的关联:揭示一种新的治疗策略
- Author:
Bing-Jie WANG
1
;
Yan ZHANG
Author Information
1. 北京大学 生命科学学院 膜生物学国家重点实验室
- Keywords:
Alzheimer's disease;
diabetes;
insulin resistance;
inflammation;
gangliosides;
mTOR
- From:
Basic & Clinical Medicine
2018;38(3):294-298
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD) is a risk factor for type 2 diabetes(T2D) and vice versa.A growing body of evidence indicates that these diseases are related both at epidemiological, clinical and molecular levels. Recent studies have begun to reveal common pathogenic mechanisms shared by AD and type 2 diabetes. Impaired neuronal insulin signaling and endoplasmic reticulum(ER) stress are found in animal models of AD,similar to observations in peripheral tissue in T2D. These findings shed light into mechanisms leading to brain dysfunction of AD in T2D patients. Here,we review the literatures on selected mechanisms shared between these diseases and discuss how the identification of such mechanisms may lead to novel therapeutic targets in AD.
