Pathogenesis of Alzheimer's disease
- VernacularTitle:阿尔茨海默病发病机制研究概述
- Author:
Zhi-Ya CHEN
1
;
Yan ZHANG
Author Information
1. 北京大学 生命科学学院 膜生物学国家重点实验室
- Keywords:
Alzheimer's disease;
molecular mechanisms;
biomarkers
- From:
Basic & Clinical Medicine
2018;38(3):289-293
- CountryChina
- Language:Chinese
-
Abstract:
Genetic studies show that there are multiple of genes involved in pathogenesis of Alzheimer's disease. Biochemistry,molecular cell biology and transgenic modeling have already uncovered some of molecular mecha-nisms; the development of chemistry,radiology and systems biology is beginning to provide useful biomarkers,and the current situation of pharmaceutical development and clinical trials are expected to change based on personalized medicine. However,in consideration of multifactoriality of the disease,we should try in different ways. In this re-view,we make a brief discussion of the most common types of dementia.