Role of endoplasmic reticulum stress in the pathogenesis of liver diseases
- VernacularTitle:内质网应激在肝脏相关疾病中的研究进展
- Author:
Wen-Bin DING
1
;
Jia-Min DAI
;
Feng ZHANG
;
Xue-Hao WANG
;
Jian-Hua RAO
Author Information
1. 南京医科大学第一附属医院 肝脏外科
- Keywords:
endoplasmic reticulum stress;
unfolded protein response;
apoptosis;
liver disease
- From:
Basic & Clinical Medicine
2018;38(2):260-264
- CountryChina
- Language:Chinese
-
Abstract:
Endoplasmic reticulum stress (ERS) is an important cellular self-protection mechanism. It can activate the unfolded protein response (UPR) that promotes cell survival, but sustained ERS may lead to cell apoptosis. There are a lot of endoplasmic reticulum in the liver cells, and many liver-related diseases are associaled with endoplasmic reticulum stress, such as alcoholic liver disease, non-alcoholic liver disease, toxic liver injury, viral hepatitis, hepatic malignant tumors and hepatic ischemia- perfusion injury. This article will summarize the role of ERS in the pathogenesis of liver-related diseases and the significance of intervention in liver disease.