Research advances of mesenchymal stem cells from bone marrow in myelodysplastic syndrome
- VernacularTitle:骨髓间充质干细胞在骨髓增生异常综合征中的研究进展
- Author:
Yan-Bin PANG
1
;
Li-Xia FAN
;
Jian-Min LUO
;
Xin DU
Author Information
1. 河北大学附属医院 血液内科
- Keywords:
myelodysplastic syndrome;
mesenchymal stem cells;
bone marrow microenvironment
- From:
Basic & Clinical Medicine
2018;38(2):255-259
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndrome (MDS) is definded as a group of clonal hematological malignancies characterized by bone marrow (BM) ineffective.hematopoiesis and increases risk for progression to acute myeloid leukemia. The altered BM mesenchymal stem cells (MSCs) play a pivotal role in the evolution and propagation of MDS. Com-pared to normal MSCs, MSCs in MDS often exhibit altered Cytogenetic, epigenetic, differentiation and functional properties, moreover, high MSCs density is associated with poor prognostic factors, which translated into a signifi-cantly diminished ability to support normal hematopoiesis, facilitates survival of malignant hematopoietic cells, ulti-mately promote disease progression and transform to acute myeloid leukemia.Therefore, characterization of key steps in the pathogenesis of MDS will lead to new approaches to treat patients with this disease.
