Research progress on exosomes in promoting bone regeneration
- VernacularTitle:外排体促进骨再生的研究进展
- Author:
Wen-Jie CHEN
1
;
Chang-Chang YIN
;
Lei-Lin YU
;
Zhong-You LI
;
Ming YIN
Author Information
1. 南昌大学 研究生院医学部
- Keywords:
bone regeneration;
exosome;
osteogenesis
- From:
Basic & Clinical Medicine
2018;38(2):251-254
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes, small vesicles of endocytic origin, have attracted attention in bone regeneration field. The vesicles travel between cells and deliver functional cargoes like proteins and RNAs, thereby regulating targeted cells dif-ferentiation, commitment, function, and proliferation. Exosomes directly regulate MSCs into the osteoblastic lineage, stimulate bone regeneration by directly regulating osteoblast proliferation and activity, regulate osteoclast maturation and activity and stimulate bone growth and regeneration by increasing vessel formation. Meantime, exosomes resolves toxicity and immunogenicity problems caused by biomaterial treatment. Furthermore, compared with living cell trans-plantation, exosomes present a lower risk for severe complication(such as tumors, emboli formation).
