Mechanism and progress of the research on the treatment of bacterial infection with bacteriophage lysin
- VernacularTitle:噬菌体裂解酶作用机制及用于细菌感染治疗的研究进展
- Author:
Dan ZHU
1
;
Si-Lu ZHU
;
Yu-Rong FU
;
Zheng-Jun YI
Author Information
1. 潍坊医学院 医学检验学系
- Keywords:
phage;
lysin;
therapy;
antibacterial mechanism
- From:
Basic & Clinical Medicine
2018;38(2):241-245
- CountryChina
- Language:Chinese
-
Abstract:
Bacteriophage lysin is characterized by high stability, wide bactericidal activity and efficacy, and safty. It is able to lyse bacteria specifically and is not susceptible to bacterial resistance. In the presence of phage, phage infecting bacteria and coding for endolysin then it lyse the bacteria, In the absence of the phage, holin assists the endolysin lysis the bacteria from external. In addition, the research progress on the treatment of Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus, Streptococcus pyogenes, and Gram-negative bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa, was also discussed in this paper.
