Research progress in the role of aquaproin-4 and inward rectifying potassium channel 4.1 in spinal cord edema
10.11817/j.issn.1672-7347.2018.05.014
- VernacularTitle:水通道蛋白-4与钾离子通道4.1在脊髓水肿中作用机制的研究进展
- Author:
Tiege CHEN
1
;
Yuexiu DANG
;
Ming WANG
;
Dongliang ZHANG
;
Yongqiang GUO
;
Haihong ZHANG
Author Information
1. 兰州大学第二医院骨科
- Keywords:
spinal edema;
aquaporin-4;
inward rectifying potassium channel 4.1;
secondary spinal cord injury;
central nervous system;
astrocyte
- From:
Journal of Central South University(Medical Sciences)
2018;43(5):552-559
- CountryChina
- Language:Chinese
-
Abstract:
Spinal edema is a very important pathophysiological basis for secondary spinal cord injury,which affects the repair and prognosis of spinal cord injury.Aquaporin-4 is widely distributed in various organs of the body,and is highly expressed in the brain and spinal cord.Inward rectifying potassium channel 4.1 is a protein found in astrocytes of central nervous system.It interacts with aquaporins in function.Aquaporin-4 and inward rectifying potassium channel 4.1 play an important role in the formation and elimination of spinal cord edema,inhibition of glial scar formation and promotion of excitotoxic agents exclusion.The distribution and function of aquaporin-4 and inward rectifying potassium channel 4.1 in the central nervous system and their expression after spinal cord injury have multiple effects on spinal edema.Studies of aquaporin-4 and inward rectifying potassium channel 4.1 in the spinal cord may provide new ideas for the elimination and treatment of spinal edema.
