Survival analysis for high-grade glioma patients who received comprehensive treatment
10.11817/j.issn.1672-7347.2018.04.008
- VernacularTitle:高级别脑胶质瘤综合治疗后生存分析
- Author:
Guiyun LIU
1
;
Rong JIANG
;
Chenyang XU
;
Jiao ZHOU
;
Fengxin LIU
;
Zhengwen HE
;
Zhigang LIU
Author Information
1. 南华大学医学院临床医学系
- Keywords:
high-grade glioma;
comprehensive treatment;
prognosis
- From:
Journal of Central South University(Medical Sciences)
2018;43(4):388-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the curative effect and prognostic factors for comprehensive therapy in patients with high-grade glioma.Methods:Patients with high-grade glioma (WHO grade Ⅲ,grade Ⅳ) were chosen from July 2008 to May 2016 in the Hunan Cancer Hospital,and a retrospective analysis was performed in 64 patients with complete follow-up data.Results:The follow-up time was 3-111 (median 29.5) months,the median overall survival time was 36.00 (95％ CI 22.85 to 49.16) months,the median progression-free survival time (PFS) was 21.00 (95％ CI 9.72 to 32.28) months,The 1-year,2-year,3-year and 5-year survival rates of high-grade glioma patients were 87.50％,56.25％,40.63％ and 17.19％,respectively.The univariate analysis of Log-Rank test and the Cox regression model analysis showed that the prognostic factors related to the prognosis of high-grade glioma patients were pathological grade,resection degree,and concurrent chemo-radiotherapy (P＜0.05).Conclusion:The overall survival time,progression-free survival time and the 5-year survival rate of patients with high-grade glioma after comprehensive treatment is partially improved.The factors relevant to the prognosis of patients with high-grade glioma are pathological grade,resection degree,and concurrent chemo-radiotherapy,indicating that the glioma patients (WHO grade Ⅲ) received total resection of the tumor and concurrent chemo-radiotherapy have better clinical effect.
