Plasma concentrations of neurotransmitters and postpartum depression
10.11817/j.issn.1672-7347.2018.03.007
- VernacularTitle:血浆神经递质浓度与产后抑郁症的关系
- Author:
Rihua XIE
1
;
Haiyan XIE
;
Krewski DANIEL
;
Guoping HE
Author Information
1. 南方医科大学南海医院护理部
- Keywords:
postpartum depression;
5-hydroxytryptamine;
norepinephrine;
neuropeptide Y;
substance P
- From:
Journal of Central South University(Medical Sciences)
2018;43(3):274-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine associations between postpartum depression (PPD) and plasma neurotransmitters.Methods:We conducted a case-control study nested to a prospective cohort established in 3 comprehensive tertiary hospitals in Changsha,Hunan,China from February to September 2007.The Chinese version of the Edinburgh Postnatal Depression Scale (EPDS) was used at 2 weeks postpartum to screen PPD,with a score of 13 or higher as the cut-off for PPD.The women with matched age but without PPD and delivery within 5 years were selected as controls.The levels of plasma monoamine neurotransmitters including serotonin (5-hydroxytryptamine,5-HT),dopamine (DA),and norepinephrine (NE),and peptide neurotransmitters including neuropeptide Y (NPY) and substance P (SP) in maternal blood samples taken at 2 weeks postpartum were measured and compared between PPD women (n=42) and controls (n=42).Results:Plasma levels of 5-HT and NPY were significantly lower while plasma levels of NE and SP were significantly higher in PPD women than those in the controls.For women with PPD,a negative correlation between NPY and NE (r=-0.36,P＜0.05) was observed.Conclusion:There are changes in plasma levels of neurotransmitters in women with PPD,and there are potential interactions between different neurotransmitters.
