Safety evaluation for medical ozone oil on skin

VernacularTitle:医用臭氧油皮肤安全性评价
Author: Jianyun LU ¹ ; Zhibing FU ; Shenglan LIU ; Jian HUANG ; Jinping LI ; Jinhua HUANG ; Yaping XIANG ; Lihua GAO ; Jie ZHANG
Author Information

1. 中南大学湘雅三医院皮肤科
Keywords: medical ozone oil; skin; irritation; acute toxicity; allergy
From: Journal of Central South University(Medical Sciences) 2018;43(2):131-138
CountryChina
Language:Chinese
Abstract: Objective:To evaluate skin irritation,acute toxicity,and allergy of medical ozone oil for clinical application.Methods:In contrast to their left and right side irritation,one or more skin irritation tests were performed on the intact and damaged skins of guinea pigs.With the maximum concentration,acute skin toxicity test was applied on the intact and damaged skins of rats.Active cutaneous anaphylaxis was applied to the guinea pigs.Results:High concentration (ozone consumption:150 g/L) of medical ozone oil showed a slight irritation on the broken skin of guinea pigs,while low concentrations did not show skin irritation.Medical ozone oil had no obvious acute toxicity to rats.The medical ozone oil and base oil showed mildallergy for the skin of guinea pig.Conclusion:The irritation of medical ozone oil is related to its concentration.With appropriateconcentration and duration of treatment,medical ozone oil is safe.