Serum interleukin-31 level and pruritus in atopic dermatitis: A Meta-analysis

VernacularTitle:血清白介素-31水平与特应性皮炎瘙痒相关性的Meta分析
Author: Jianyun LU ¹ ; Kathy WU ; Qinghai ZENG ; Yaping XIANG ; Lihua GAO ; Jinhua HUANG
Author Information

1. 中南大学湘雅三医院皮肤科
Keywords: interleukin-31; dermatitis; atopic; pruritus; Meta-analysis
From: Journal of Central South University(Medical Sciences) 2018;43(2):124-130
CountryChina
Language:Chinese
Abstract: Objective:To investigate associations of interleukin-31 (IL-31) and pruritus in atopic dermatitis (AD) with Meta-analysis.Methods:Materials were extracted from the citations listed in the following databases:PubMed,Science Direct,Web of Science and Cochrane.Key search terms included:atopic dermatitis,pruritus,and IL-31.The Meta-analysis was used to analyze the correlation between pruritws in AD and IL-31 expression level.Results:The Meta-analysis showed that serum IL-31 levels were higher in AD patients than those in the healthy controls.The levels of IL-31 were higher in severe AD patients than those in the mild and moderate AD patients.Moreover,a positive correlation between serum IL-31 levels and severity of pruritus was identified.Conclusion:Increased serum levels of IL-31 generally exist in the AD patients,and it may accelerate the pruritus in the AD patients.