Expression of transforming growth factor 1 and bone morphogenetic protein 9 in human nonunion tissues and its clinical significance
10.11817/j.issn.1672-7347.2018.01.008
- VernacularTitle:转化生长因子β1和骨形态发生蛋白-9在人骨不连组织中的表达及其临床意义
- Author:
Chunfeng LIU
1
;
Wenqi LIU
;
Tang LIU
;
Xiaoping LIU
;
Zhen WANG
;
Jinlian LIU
;
Chaoqun LIU
Author Information
1. 上海交通大学医学院苏州九龙医院骨科
- Keywords:
nonunion;
transforming growth factor 1;
bone morphogenetic protein-9;
immunohistochemistry
- From:
Journal of Central South University(Medical Sciences)
2018;43(1):49-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the expression of transforming growth factor I(TGF-β1) and bone morphogenetic protein-9 (BMP-9) in human nonunion tissues,and to evaluate the clinical significance.Methods:The number of hypertrophic nonunion tissue samples and atrophic nonunion tissue samples were collected from Department of Orthopedics,the Second Xiangya Hospital of Central South University and Suzhou Kowloon Hospital Affiliated to School of Medicine of Shanghai Jiao Tong University between 2010 and 2014.Semi-quantification of SP immunohistochemical method and pathological image analysis software IPP6.0 were used to analyze the expression of TGF-β1 and BMP-9.Nonunion type,patients' age and nonunion time were statistical analyzed.Results:The absorbance values of TGF-β1 and BMP-9 in the hypertrophic nonunion tissues were 0.3236±0.0390 and 0.1337±0.0400,respectively;while the absorbance values of TGF-β1 and BMP-9 in the atrophic nonunion tissues were 0.3191±0.0369 and 0.1373±0.0423,respectively,with no significant difference between the two types of tissues (both P＞0.05).There was also no significant difference in patients' age and bone nonunion time between them (all P＞0.05).Conclusion:There is no significant difference in osteogenic potential between the hypertrophic nonunion tissues and the atrophic nonunion tissues.
