Progress in the study on roles of cathepsin in hypertension
10.11817/j.issn.1672-7347.2017.12.014
- VernacularTitle:组织蛋白酶在高血压中作用的研究进展
- Author:
Zhouyangfan PENG
1
;
Yapei LI
;
Pingyu ZENG
;
Xiaohui LI
Author Information
1. 中南大学药学院药理学系
- Keywords:
cathepsin;
hypertension;
myocardial remodeling;
vascular injury
- From:
Journal of Central South University(Medical Sciences)
2017;42(12):1447-1451
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular remodeling or dysfunction-induced abnormal cardiac output,blood volume and peripheral vascular resistance is an important pathophysiological mechanism for the occurrence and development of hypertension.Cathepsins are widely expressed in human various tissue and cells and they are involved in the pathogenesis of hypertension through activation of renin-angiotensin system,degradation of cytoplasmic matrix,proliferation of smooth muscle cell and hypertrophy of myocyte.The clinical studies have found that cathepsins can be used as a biomarker for hypertension.In recent years,the studies on the functions and mechanisms of cathepsins have provided a new sight and strategy for treatment of hypertension.
