Relationship between the gene polymorphisms of oxidative metabolism enzyme of exogenous chemicals and the susceptibility to neoplasms
10.11817/j.issn.1672-7347.2017.12.013
- VernacularTitle:外源化学物氧化代谢酶基因多态性与肿瘤易感性
- Author:
Guanghui XIA
1
;
Jian'an HU
Author Information
1. 中南大学湘雅公共卫生学院劳动卫生与环境卫生学系
- Keywords:
cytochrome P450;
cyclooxygenase 2;
lipoxygenase;
gene polymorphisms;
neoplasms
- From:
Journal of Central South University(Medical Sciences)
2017;42(12):1439-1446
- CountryChina
- Language:Chinese
-
Abstract:
The gene polymorphisms of human being will cause abnormality in the expression of corresponding gene,which is closely related to the physiological function and disease.Cytochrome P450,cyclooxygenase and lipoxygenase are vital enzymes that mediated the oxidative metabolism process for exogenous chemicals,and play important roles in activating the indirect carcinogens and metabolizing clinical drug;the gene polymorphisms of these enzymes can change the expression and activity of enzymes,affect the metabolic transformation of carcinogens,and then give rise to difference in the susceptibility to neoplasms.Studying the relationship between the gene polymorphisms of oxidative metabolism enzyme for endogenous and exogenous chemicals and the susceptibility to neoplasms can provide scientific basis for probing into the genetic markers and the pathogenesis of neoplasms.
