Clinical characteristics of hemichorea associated with non-ketotic hyperglycemia in 3 patients: case report and literature review
10.11817/j.issn.1672-7347.2017.11.016
- VernacularTitle:非酮症高血糖偏侧舞蹈症3例临床特征分析并文献复习
- Author:
Yacen HU
1
;
Yafang ZHOU
;
Fang YI
;
Lingyan YAO
;
Hongwei XU
;
Lin ZHOU
Author Information
1. 中南大学湘雅医院老年病学神经内科
- Keywords:
diabetes mellitus;
non-ketotic hyperglycemia;
hemichorea;
magnetic resonance imaging
- From:
Journal of Central South University(Medical Sciences)
2017;42(11):1341-1347
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the pathophysiology,clinical manifestation and neuroimaging characteristics and therapeutic experiences for hemichore associated with non-ketotic hyperglycemia (HC-NH).Methods:Clinical data of three patients with HC-NH from Xiangya Hospital,Central South University were analyzed retrospectively,and the related literature was reviewed.Results:The core clinical features of HC-NH were characterized by acute/subacute onset of hemichorea with non-ketotic hyperglycemia in the elderly females.Radiologic findings associated with HC-NH were characterized by hyperattenuation on computed tomographic (CT) scans and hyperintensity on Tl-weighted magnetic resonance imaging (MRI) at unilateral basal ganglion region.Blood glucose control was the foundation of treatment.Dopamine receptor antagonists and benzodiazepine sedative were helpful in controlling hemichorea.Conclusion:Hemichorea-hemiballismus is a rare complication of nonketotic hyperglycaemia in elderly type 2 diabetes.It is associated with contralateral striatal radiological abnormality and typically T1 hyperintensity on MRI.The pathophysiology of HC-NH is not clear.The prognosis of HC-NH is favorable.Antidiabetic drugs combined with dopamine receptor antagonists can effectively relieve the hemichorea symptoms.
