New drug developments of snake venom polypeptides and progress
10.11817/j.issn.1672-7347.2017.11.015
- VernacularTitle:蛇毒多肽的新药研发进展
- Author:
Sihai FU
1
;
Mei FENG
;
Yan XIONG
Author Information
1. 广州医科大学药学院
- Keywords:
snake venom;
polypeptides;
new drug;
development
- From:
Journal of Central South University(Medical Sciences)
2017;42(11):1334-1340
- CountryChina
- Language:Chinese
-
Abstract:
The value of snake venom polypeptides in clinical application has drawn extensive attention,and the development of snake polypeptides into new drugs with anti-tumor,anti-inflammatory,antithrombotic,analgesic or antihypertensive properties has become the recent research hotspot.With the rapid development of molecular biology and biotechnology,the mechanisms of snake venom polypeptides are also gradually clarified.Numerous studies have demonstrated that snake venom polypeptides exert their pharmacological effects by regulating ion channels,cell proliferation,apoptosis,intracellular signaling pathway,and expression of cytokine as well as binding to relevant active sites or receptors.
