Therapeutic Effects and Mechanism of Chinese Medicine Skin Dialysis for Chronic Renal Failure
10.13359/j.cnki.gzxbtcm.2018.02.005
- VernacularTitle:中药皮肤透析疗法治疗慢性肾衰竭的疗效及其机制研究
- Author:
Qin-Xiang TAN
1
;
Guo-Zi CHEN
;
Liu-Chang FENG
;
Li-Liang WEI
;
Xu-Sheng LIU
Author Information
1. 北京中医药大学深圳医院
- Keywords:
chronic renal failure;
Chinese medicine skin dialysis;
TCM syndromes;
microinflammation;
therapeutic efficacy;
mechanism
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2018;35(2):221-226
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of Chinese medicine skin dialysis on traditional Chinese medicine (TCM) syndrome scores and microinflammation in patients with chronic renal failure(CRF). Methods A total of 180 patients with CRF were divided into groups A, B and C, 60 cases in each group. All of the 3 groups were given conventional treatment, and additionally, group A was given Chinese medicine skin dialysis, and group B was given pure water dialysis. Meanwhile, 60 healthy volunteers served as normal control group (group D), and had no any medication. The course of treatment lasted for one month. Before and after treatment, we examined the scores of TCM syndromes and the levels of 24-hour urinary protein, serum creatinine (SCr), blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), albumin (ALB), immunoglobulin A(IgA), immunoglobulin G (IgG) , immunoglobulin M(IgM), interleukin 6 (IL-6) , interleukin 1(IL-1), hyper-sensitive C reactive protein (hs-CRP), and tumor necrosis factor alpha (TNF-α). Results After treatment, the scores of TCM syndromes and the levels of 24-hour urinary protein, SCr, BUN, eGFR, IL-6, IL-1, hs-CRP, and TNF-α in the 3 groups were decreased (P < 0.05 compared with those before treatment), and were markedly lower in group A than those in group B and group C (P<0.05); serum levels of IgA, IgG, IgM and ALB in the 3 groups were increased(P < 0.05 compared with those before treatment), and the levels in group A were significantly higher than those in group B and group C (P < 0.05). However, the levels of observation indexes did not arrive to the levels of group D(P<0.05). Conclusion Chinese medicine skin dialysis is effective on relieving the symptoms of CRF patients and enhancing the therapeutic effect through decreasing inflammatory mediators, inhibiting micro-inflammation and improving nutritional status.
