A meta-analysis of Kangai injection combined with chemotherapy in treating colorectal cancer
10.3760/cma.j.issn.1673-4246.2018.07.010
- VernacularTitle:康艾注射液辅助化疗治疗大肠癌的meta分析
- Author:
Weiqing ZHANG
1
;
Zhulin WU
;
Li HE
;
Lisheng PENG
Author Information
1. 518033,广东省深圳市中医院肿瘤科
- Keywords:
Intestinal neoplasms;
Kangai injection;
Chemotherapy;
Injectio (TCD);
Meta-analysis
- From:
International Journal of Traditional Chinese Medicine
2018;40(7):616-621
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effect and safety of Kangai injection combined with Chemotherapy in treating Colorectal cancer. Methods The CNKI, Wanfang, CBM, VIP, Medline and Cochrane Library from inception to the August 17th 2017 were searched, and all the relevant journals, and the literature of RCTs were enrolled. The quality of RCTs was assessed by Jadad scores, meta-analyses were performed by Review Manager 5.3 software. Results 21 Chinese articles were enrolled, including three high quality article, and the Jadad average score is 2.7. 1 879 patients were included. The result of Meta-analyses showed that intervention could improve the quality of life [OR=3.29, 95% CI (2.53-4.27), P＜0.01]; improve the short-term effects [OR=1.79, 95% CI (1.36-2.37),P＜0.001]; reduce the gastrointestinal reactions [OR=0.36,95% CI (0.29-0.45), P＜0.01], reduce bone marrow suppression reaction [OR=0.35, 95% CI (0.27-0.44),P＜0.01]. reduce the peripheral neurotoxicity [OR=0.57, 95% CI (0.41-0.78), P＜0.01], improve the abnormal liver function [OR=0.0.41,95% CI (0.26-0.65), P＜0.01], and improve the abnormal renal function [OR=0.55,95% CI (0.31-0.98), P=0.04]. Conclusions The combination of Kangai injection and Chemotherapy in treating Colorectal cancer is better than only using chemotherapy. However, we need more high-quality RCTs to improve the research.
