Study of Shenling-Baizhu granule combined with saccharomyces boulardii treatment for pediatric antibiotic associated diarrhea
10.3760/cma.j.issn.1673-4246.2018.07.009
- VernacularTitle:参苓白术颗粒联合布拉氏酵母菌散治疗小儿抗生素相关性腹泻临床研究
- Author:
Jufang LEI
1
;
Liping YU
;
Na ZHANG
Author Information
1. 435000,鄂东医疗集团黄石市妇幼保健院新生儿科
- Keywords:
Diarrhea;
Child;
Antibiotic associated;
Shenling-Baizhu granule;
Saccharomyces boulardii
- From:
International Journal of Traditional Chinese Medicine
2018;40(7):613-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe Shenling-Baizhu granule combined with saccharomyces boulardii treatment for pediatric antibiotic associated diarrhea (AAD). Methods A total of 146 children with AAD were randomly divided into the control group (n=73) and the observation group (n=73). The control group received the saccharomyces boulardii, and the observation group received saccharomyces boulardii and Shenling-Baizhu granule, with a course of 5 days. The CD4 and CD8 T lymphocytes were detected by flow cytometry. The stool frequency, stool frequency recovery time, and clinic effects were compared. Results The stool frequency (3.0 ± 0.4 times/d vs. 3.6 ± 0.4 times/d, t=2.624), stool frequency recovery time (3.2 ± 0.6 d vs. 4.5 ± 0.8 d, t=2.641), and recovery time (4.1 ± 0.8 d vs. 5.3 ± 1.1 d, t=2.522) in observation group were significantly lower than those in control group ( P＜0.05). After the treatment, the CD4+(38.65% ± 5.74% vs. 33.72% ± 5.23%, t=2.452), CD4+/CD8+(1.92 ± 0.38 vs. 1.45 ± 0.26, t=2.483) of the observation group was significantly higher than those of the control group, and the CD8+(20.15% ± 3.16% vs. 23.21% ± 3.44%, t=2.483) of the observation group was significantly lower than this of the control group (P＜0.05). The rate of clinic effects was 93.2% (68/73) in observation group, which was higher than 80.8% (59/73) in control group (χ2=2.446, P＜0.05). Conclusions The Shenling-Baizhu granule combined with saccharomyces boulardii could enhance the immune function in children with AAD with significant clinical efficacy.
