Clinical study on TCM enema combined with continuous renal replacement therapy on the treatment of severe acute renal injury
10.3760/cma.j.issn.1673-4246.2018.05.008
- VernacularTitle:中药灌肠配合连续性肾脏替代疗法治疗重症急性肾损伤临床研究
- Author:
Shang LI
1
;
Xia ZHI
;
Cong LI
;
Xiaoyi FAN
Author Information
1. 053000,河北省衡水市人民医院神经外科
- Keywords:
Acute kidney injury;
Enema;
Compounds (TCD);
Hemodiafiltration;
Blood urea nitrogen;
Serum creatinine;
Cys C
- From:
International Journal of Traditional Chinese Medicine
2018;40(5):414-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of TCM enema combined with continuous renal replacement therapy on the treatment of severe acute renal injury. Methods A total of 100 patients of severe AKI patients were divided into 2 groups by random digital table, each of which was 50 cases. The control group was treated with CRRT, and the observation group cooperated with the traditional Chinese medicine enema on the basis of the control group. The 2 groups were treated continuously for 14 d. The renal function and urine volume recovery time were observed; 24 h urinary protein and 24 h urinary albumin excretion rate were determined by automatic biochemical analyzer.The blood urea nitrogen (BUN), serum creatinine (SCr), serum cystatin C (Cys C) were detected. And theclinical efficacy was compared between the two groups. Results The total effective rate of the observation group was 70.0％ (35/50) and the control group was 50.0％ (25/50). The difference between the 2 groups was statistically significant. After treatment, the levels of serum BUN (6.51 ± 1.07 mol/L vs. 8.22 ± 2.31 mol/L, t=4.750), SCr (91.29 ± 21.05 μmol/L vs. 108.67 ± 19.34 μmol/L, t=4.299) and Cys C (0.85 ± 0.33 mg/L vs. 1.03 ± 0.45 mg/L, t=2.281) in the observation group were significantly lower than those of the control group (P<0.01 or P<0.05). The urinary albumin excretion rate of 24 h urine protein (115.37 ± 26.15 mg/24 h vs. 167.55 ± 38.66 mg/24 h, t=7.905) and 24 h urine (198.41 ± 33.24 μg/min vs. 226.19 ± 38.35 μg/min, t=3.871) was significantly lower than that of the control group (P<0.01). Conclusions TCM enema combined with CRRT can promote the recovery of renal function in patients with severe AKI, can effectively delay the progression of renal injury.
