Study on extraction and clathration process of volatile oil in Tianma-Shouwu tablet
10.3760/cma.j.issn.1673-4246.2018.04.016
- VernacularTitle:天麻首乌片中挥发油的提取及包合工艺研究
- Author:
Wenqiao SU
1
;
Yuehui LI
;
Yin WANG
;
Lihua ZHU
;
Yanmei PENG
Author Information
1. 湖南中医药大学
- Keywords:
Volatile oils;
Tianma-Shouwu tablet;
Orthogonal test;
β-cyclodextrin;
Central composite design
- From:
International Journal of Traditional Chinese Medicine
2018;40(4):357-362
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the extraction and β-cyclodextrin clathration process of volatile oil in Tianma-Shouwu tablet.Methods The extraction of volatile oil was optimized through the orthogonal design L9(34) with the volatile oil extraction amount as assessment index. The saturated aqueous solution preparation of clathrate form was used. The volume of β-cyclodextrin and volatile oil, clathration temperature, clathration time was investigated by central composite design-response surface methodology, with the score of volatile oil inclusion ratio and utilization ratio as the index. The results were fitted by second-order polynomial equation, and then the best clathration process was determined. Results The optimization extraction process of volatile oil in Tianma-Shouwu tablet was as follows:to add 8 times water,immerse 30 minutes,steam distill 6 hours;and the best clathration process was as follows: the ratio of β-cyclodextrin and volatile oil was 9.50:1, clathration temperature 43 ℃, and clathration time 4.2 hours. Conclusions The optimized extraction and clathration process were reasonable, stabled and repeatable.
