The clinical study of Bushen-Qingxin decoction for the patients with premature ovarian failure with kidney deficiency
10.3760/cma.j.issn.1673-4246.2018.04.005
- VernacularTitle:自拟补肾清心汤治疗肾虚型卵巢功能早衰临床研究
- Author:
Yahong WANG
1
;
Shuling RAN
;
Hongwei LIU
;
Yanyun ZHANG
;
Ruiyu GU
Author Information
1. 064000,河北省唐山市丰润区第二人民医院妇产科
- Keywords:
Ovary;
Progeria;
Bushen-Qingxin decoction;
Estrogen replacement therapy;
Clinical study
- From:
International Journal of Traditional Chinese Medicine
2018;40(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of Bushen-Qingxin decoction for the patients with premature ovarian failure (POF) with kidney deficiency type. Methods A total of 120 POF patients were randomly divided into the observation group and the control group. The observation group were treated with Bushen-Qingxin decoction. The control group were treated with hormone replacement therapy (HRT). After continuous treatment for 3 courses, the clinical efficacy, clinical symptoms and the levels of estrogen (E2), luteotropic hormone (LH), follicle-stimulating hormone (FSH) were comparedbefore and after treatment. Results The total effective rate in the observation group was 86.7% (52/60), and the control group was 60.0% (36/60). The difference was statistically significant (x2=9.588, P=0.002) between two groups. The symptoms aversion to cold, and cold limbs, depressed mood, night sweats were improved significantly better than those in the control group(x2=16.464,16.214,11.525,9.938,P<0.001).After treatment,the serum E2(88.32 ± 9.35 pmol/L vs. 62.10 ± 7.22 pmol/L, t=17.848) in the observation group was significantly higher than this in the control group,while the serum FSH(32.33 ± 4.60 U/L vs.46.82 ± 5.47 U/L,t=15.704),LH(24.80 ± 3.37 U/L vs.32.16 ± 4.02 U/L, t=10.868) in the observation group were significantly lower than those in the control group (P<0.01). In the follow-up of 3 months, the recurrence rate in the observation group was 3.8% (2/52), but 16.7% (6/36) in the control group. The difference was statistically significant between two groups (x2=4.231, P=0.040).Conclusions The Bushen-Qingxin decocation can significantly improve the clinical symptoms and restore ovarian function.The Bushen-Qingxin decocation is an effective method for the treatment of premature ovarian failure.
