Determination of thiabendazole in honeysuckle flower by LC-MS/MS

VernacularTitle:液相色谱-质谱法测定金银花中噻菌灵的残留量
Author: Jun ZHU ¹ ; Bing SHANG ; Xueru DING ; Lin XIONG ; Qinhua CHEN
Author Information

1. 湖北医药学院附属东风医院药学部
Keywords: Lonicerae Japonicae Flos; Liquid chromatography-mass spectrometry; Thiabendazole
From: International Journal of Traditional Chinese Medicine 2018;40(3):258-261
CountryChina
Language:Chinese
Abstract: Objective To establish a rapid and sensitive liquid chromatograph-mass spectrometry (LC-MS/MS) method for the determination of thiabendazole in honeysuckle flowers. Methods The acetic ether was selected as extraction solvent. The mass spectrometer analysis was conducted in the positive ionization electrospray mode using SIM. The transitions m/z 202→175 was used to quantify thiabendazole. Results The satisfactory linearity was obtained in the range of 0.1×10-5-2×10-5mg for thiabendazole (r=0.999 5), and the limit of detection (LOD) of 10.0 ng/ml and the mean recovery of 93.70% were obtained by this LC-MS/MS method. Conclusions The method of LC-MS/MS is sensitive, simple and accurate, and it proved to be suitable for the determination of thiabendazole in Honeysuckle flowers.